Last gameday, both teams from the same city, sharing the very same stadium. This is a derby game and even though Santa Fe have a big advantage in recent head to head clashes, I cannot see them as favourites right now.
Coach himself claimed that the team has a very tough schedule with Libertadors games, sometimes 15 hours trips with no sleep and also that Libertadores is priority and that's why he rested regulars against Atletico Nacional last week. Now situation is the same – they have a game against Internacional for Copa in midweek which is priority for them.
This is the table in Colombia right now. Four of those five teams will proceed to the next stage. Independiente will face Envigado's reservers (do not underestimate them, though) , Junior has an away visit to Boyaca, Tolima with a game they should win quite easy. It depends a lot on the development on how the other games proceed but hosts will surely try to push the less they can, in last minutes may even give away everything in order to be fresh for game in Brazil. And even if they do not proceed here, this really wouldn't be the end of the world for them.
Independiente Medellin 19 32
Club Santa Fe 19 31
Millonarios 19 31
Junior Barranquilla 19
Deportes Tolima 19 30
Millionarios currently on a great unbeaten run, key players Ochoa and Nunez are confirmed do play after experiencing some troubles. They showed really good attack, Agudelo is absent but stil we ahve Uriba and very good holding midfielders.
In such circumstances, having in mind how big are stakes for hosts, I expect an even game, maybe Millionarios as short favoruites here.