Christian Benteke will serve the second game of a three match ban here but was able to step up his fitness on international duty with Belgium.
Ron Vlaar and Philippe Senderos both picked up knocks on international duty, while Nathan Baker is also a doubt having picked up a knee injury at West Ham.
That could mean there is a rare chance for Jores Okore to start at the back, while Lambert will hope to have Alan Hutton back available for the visit of Southampton.
Dusan Tadic and Morgan Schneiderlin were both forced to withdraw from international duty with minor injuries but should be in contention by Monday.
Steven Davis was forced off against Leicester last time out but will also hope to be fit ahead of the meeting with his former club.
Shane Long will hope that his brace ahead of the international break will earn him a start but the form of Sadio Mané leaves Ronald Koeman with a selection dilemma.
21:00 Aston Villa – Southampton